According to the Biology of Kundalini, there are significant hormonal implications of a Kundalini Awakening.
The hyperactivity of the HPA axis and sympathetic nervous system is perhaps one of the reasons why excessive kundalini activity can make one feel out there, that and the excessive production of opiates of course. A sustained stress response of the HPA-axis eventually depletes the adrenal glands. When the HPA-axis is imbalanced or burned out, the body depletes itself of strength trying to achieve homeostasis. When the stress-response hormones, epinephrine and norepinepthrine, are released a fight or flight response happens, such as an increased in heart rate. Also, imbalances of norepinephrine may cause depression or ADD. In those who are depressed the ‘safety memory’ mechanism of the prefrontal lobes might not be working well. Instead, they are chronically overworking the fight or flight response and burning out the adrenals and thyroid.
The endocrine system and the nervous system work together as biological conductors. This symphony of systems harmoniously meet in the hypothalamus gland and then the pituitary gland. The hypothalamus, triggered by stress, secretes hormones that tell the pituitary gland what hormones to secrete. Once it secretes a releasing hormone, the pituitary secrets a stimulating hormone, and a corresponding endocrine gland secretes a hormone that commands a biological function.
The adrenal-cortex and the adrenal-medulla make up the adrenal gland, which sits on top of the kidneys. The adrenal medulla secretes hormones that regulate metabolism, blood-composition, and even body shape. It releases the hormones epinephrine and norepinephrine, which are key to the fight or flight response. Adrenaline causes increased heart rate, constricted blood vessels, and dilated air ways. Norepinephrine is similar. It increases heart rate, triggers glucose release, and increases blood flow to muscles. It does this by causing muscles to tense, increasing blood pressure, which, in turn triggers a reflex of the heart to beat harder and faster. This constriction of blood vessels also reduces blood-flow to cognitive parts of the brain in particular the prefrontal cortex, and diverts it to parts of the brain implicated with survival faculties.